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Overview
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YAP is a protein encoded by the YAP1 gene which is approximately 54, 5 kDa. YAP is localised to the cytoplasm and nucleus. It is involved in the regulation of lipid metabolism, signalling by ERBB4, gene expression and hippo signalling pathway. It is a downstream nuclear effector of the Hippo signalling pathway which is involved in development, growth, repair, homeostasis and tumor suppression by restricting proliferation and promoting apoptosis. The YAP1 gene is known to play a role in the development and progression of multiple cancers as a transcriptional regulator of this signalling pathway and may function as a potential target for cancer treatment. YAP is expressed in the liver, lung, nervous system, pancreas and skin. Mutations in the YAP1 gene may result in Coloboma, cleft lip or palete and Huntington disease. STJ96289 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of YAP protein.
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