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Overview
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WAVE2 is a protein encoded by the WASF2 gene which is approximately 54, 2 kDa. WAVE2 is localised to the cytoplasm and is involved in regulation of actin dynamics for phagocytic cup formation, innate immune system, signalling by Rho GTPases and RET signalling. It is a downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton and is expressed in all tissues. Mutations in the WASF2 gene may result in Wiskott-Aldrich syndrome and depression. STJ96263 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of WAVE2 protein.
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