Name: Anti-UBE2D2 antibody
Price: 297.00 USD

Overview
- Regulated degradation of misfolded, damaged or short-lived proteins in eukaryotes occurs via the ubiquitin (Ub)-proteasome system (UPS). An integral part of the UPS system is the ubiquitination of target proteins and covalent linkage of Ub-containing proteins to form polymeric chains, marking them as targets for 26S proteasome-mediated degradation. Ubiquitination of proteins is mediated by a cascade of enzymes which includes E1 (ubiquitin activating), E2 (ubiquitin conjugating), and E3 (ubiquitin ligases) enzymes. This gene encodes a member of the E2 enzyme family. Substrates of this enzyme include the tumor suppressor protein p53 and peroxisomal biogenesis factor 5 (PEX5). Alternative splicing results in multiple transcript variants of this gene.
  
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Properties
- Host
  
  rabbit
  
  Antibody Type
  
  polyclonal
  
  Isotype
  
  IgG
  
  Reactivity
  
  human; mouse; rat
  
  Immunogen
  
  Recombinant fusion protein containing a sequence corresponding to amino acids 1-147 of human UBE2D2 (NP_003330. 1).
  
  Purification
  
  Affinity purification
  
  Conjugate
  
  Unconjugated
  
  Formulation
  
  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  
  Storage
  
  Store at -20°C and avoid freeze-thaw cycles.
  
  Regulatory Status
  
  RUO
  
  Antigen
  
  Ubiquitin-Conjugating Enzyme E2 D2; (E3-Independent E2 Ubiquitin-Conjugating Enzyme D2; E2 Ubiquitin-Conjugating Enzyme D2; Ubiquitin Carrier Protein D2; Ubiquitin-Conjugating Enzyme E2(17kb 2; Ubiquitin-Conjugating Enzyme E2-17 Kda 2; Ubiquitin-Protein Ligase D2; P53-Regulated Ubiquitin-Conjugating Enzyme 1 (Gene ID:7322; UniProt:P62837)
  
  * For research use only