Name: Anti-UBE2D1 antibody
Price: 297.00 USD

Overview
- The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is closely related to a stimulator of iron transport (SFT), and is up-regulated in hereditary hemochromatosis. It also functions in the ubiquitination of the tumor-suppressor protein p53 and the hypoxia-inducible transcription factor HIF1 alpha by interacting with the E1 ubiquitin-activating enzyme and the E3 ubiquitin-protein ligases. Two transcript variants encoding different isoforms have been found for this gene.
  
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Properties
- Host
  
  rabbit
  
  Antibody Type
  
  polyclonal
  
  Isotype
  
  IgG
  
  Reactivity
  
  human; mouse; rat
  
  Immunogen
  
  Recombinant fusion protein containing a sequence corresponding to amino acids 1-147 of human UBE2D1 (NP_003329. 1).
  
  Purification
  
  Affinity purification
  
  Conjugate
  
  Unconjugated
  
  Formulation
  
  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  
  Storage
  
  Store at -20°C and avoid freeze-thaw cycles.
  
  Regulatory Status
  
  RUO
  
  Antigen
  
  Ubiquitin-Conjugating Enzyme E2 D1; (E3-Independent E2 Ubiquitin-Conjugating Enzyme D1; E2 Ubiquitin-Conjugating Enzyme D1; Stimulator Of Fe Transport; Sft; Ubc4/5 Homolog; Ubch5; Ubiquitin Carrier Protein D1; Ubiquitin-Conjugating Enzyme E2(17kb 1; Ubiquitin-Conjugating Enzyme E2-17 Kda 1; Ubiquitin-Protein Ligase D1 (Gene ID:7321; UniProt:P51668)
  
  * For research use only