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Overview
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Tom20 is a protein encoded by the TOMM20 gene which is approximately 16, 2 kDa. Tom20 is localised to the mitochondrion outer membrane and is involved in deubiquitination, metabolism of proteins, pink/parkin mediated mitophagy, and glucose/energy metabolism. It is a central component of the receptor complex responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. TOM22 functions as the transit peptide receptor at the surface of the mitochondrion outer membrane and facilitates the movement of preproteins into the TOM40 translocation pore. Tom20 is expressed in the nervous system, bone marrow, pancreas, eye and liver. Mutations in the TOMM20 gene result in Perry syndrome and infantile neuroaxonal dystrophy. STJ96061 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of Tom20 protein.
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