Name: Anti-TNFRSF1A antibody
Price: 297.00 USD

Overview
- This gene encodes a member of the TNF receptor superfamily of proteins. The encoded receptor is found in membrane-bound and soluble forms that interact with membrane-bound and soluble forms, respectively, of its ligand, tumor necrosis factor alpha. Binding of membrane-bound tumor necrosis factor alpha to the membrane-bound receptor induces receptor trimerization and activation, which plays a role in cell survival, apoptosis, and inflammation. Proteolytic processing of the encoded receptor results in release of the soluble form of the receptor, which can interact with free tumor necrosis factor alpha to inhibit inflammation. Mutations in this gene underlie tumor necrosis factor receptor-associated periodic syndrome (TRAPS), characterized by fever, abdominal pain and other features. Mutations in this gene may also be associated with multiple sclerosis in human patients.
  
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Properties
- Host
  
  rabbit
  
  Antibody Type
  
  polyclonal
  
  Isotype
  
  IgG
  
  Reactivity
  
  human; mouse
  
  Immunogen
  
  Recombinant fusion protein containing a sequence corresponding to amino acids 22-211 of human TNFRSF1A (NP_001056. 1).
  
  Purification
  
  Affinity purification
  
  Conjugate
  
  Unconjugated
  
  Formulation
  
  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  
  Storage
  
  Store at -20°C and avoid freeze-thaw cycles.
  
  Regulatory Status
  
  RUO
  
  Antigen
  
  Tumor Necrosis Factor Receptor Superfamily Member 1a; Tumor Necrosis Factor Receptor 1; Tnf-R1; Tumor Necrosis Factor Receptor Type I; Tnf-Ri; Tnfr-I; P55; P60; Cd Antigen Cd120a Cleaved Into-Tumor Necrosis Factor Receptor Superfamily Member 1a-Membrane Form-Tumor Necrosis Factor-Binding Protein 1; Tbpi (Gene ID:7132; UniProt:P19438)
  
  * For research use only