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Overview
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Tak1 is a protein encoded by the MAP3K7 gene which is approximately 67, 1 kDa. Tak1 is localised to the cytoplasm and cell membrane. It is involved in activated TLR4 signalling, toll-like receptor signalling pathways, IL-17 family signalling pathways and RANK signalling in osteoclasts. It is a serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. It plays an important role in the cascades of cellular responses evoked by changes in the environment. It also mediates the signalling transduction induced by TGF beta and morphogenetic protein, and controls a variety of cell functions including transcription regulation and apoptosis. Tak1 is expressed in the blood, liver, lung and in the cells of the nervous system. Mutations in the MAP3K7 gene may result in front metaphyseal dysplasia. STJ95901 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of Tak1 protein.
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