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Overview
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Syndecan-4 is a protein encoded by the SDC4 gene which is approximately 21, 6 kDa. Syndecan-4 isoform 1 is localised to the cell membrane and isoform 2 is secreted. It is involved in glycosaminoglycan metabolism, metabolism of fat-soluble vitamins, wnt signalling pathways and non-integrin membrane-ECM interactions. It is a transmembrane that functions as a receptor in intracellular signalling. The encoded protein is found as a homodimer and is a member of the syndecan proteoglycan family. It also regulates exosome biogenesis in concert with SDCBP and PDCD6IP. Syndecan-4 is expressed in epithelial and fibroblastic cells. STJ95856 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of Syndecan-4 protein.
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