Anti-SNAI 1 antibody

Anti-SNAI 1 antibody

Catalog Number:
A001051086STJ
Mfr. No.:
STJ95716
Price:
$224
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      • Overview
        • SNAI 1 is a protein encoded by the SNAI1 gene which is approximately 29 kDa. SNAI 1 is localised to the cytoplasm and nucleus. It is involved in the development HGF signalling pathway and embryonic and induced pluripotent stem cell differentiation pathways and lineage-specific markers. It plays a role in the induction of the epithelial to mesenchymal transition, formation and maintenance of embryonic mesoderm, growth arrest, survival and cell migration. It binds to 3 E-boxes of the E-cadherin/CDH1 gene promoter and to the promoters of CLDN7 and KRT8 and, in association with histone demethylase KDM1A, causes a decrease in dimethylated H3K4 levels and represses transcription. SNAI 1 is expressed in a variety of tissues with the highest expression in kidney. Mutations in the SNAI1 gene may result in cercarial dermatitis and fasciolopsiasis. STJ95716 was affinity purified. This poly clonal antibody binds SNAI 1.

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      • Properties
        • Host
          rabbit
          Antibody Type
          polyclonal
          Isotype
          IgG
          Reactivity
          human; mouse; monkey
          Immunogen
          Synthesized peptide derived from human SNAI 1 around the non-phosphorylation site of S246.
          Purification
          The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
          Conjugate
          Unconjugated
          Formulation
          Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
          Storage
          Store at -20°C and avoid repeat freeze-thaw cycles.
          Concentration
          1 mg/ml
          Regulatory Status
          RUO
          Antigen
          Zinc Finger Protein Snai1; Protein Snail Homolog 1; Protein Sna (Gene ID:6615; UniProt:O95863)

          * For research use only

      • Applications
        • Application
          WB; IHC (paraffin); IF; ELISA
        • Application Dilutions
          WB 1:500-1:2000
          IHC 1:100-1:300
          IF 1:200-1:1000
          ELISA 1:5000

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