Name: Anti-SMAD7 antibody
Price: 297.00 USD

Overview
- The protein encoded by this gene is a nuclear protein that binds the E3 ubiquitin ligase SMURF2. Upon binding, this complex translocates to the cytoplasm, where it interacts with TGF-beta receptor type-1 (TGFBR1), leading to the degradation of both the encoded protein and TGFBR1. Expression of this gene is induced by TGFBR1. Variations in this gene are a cause of susceptibility to colorectal cancer type 3 (CRCS3). Several transcript variants encoding different isoforms have been found for this gene.
  
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Properties
- Host
  
  rabbit
  
  Antibody Type
  
  polyclonal
  
  Isotype
  
  IgG
  
  Reactivity
  
  mouse; rat
  
  Immunogen
  
  A synthetic peptide corresponding to a sequence within amino acids 1-100 of human SMAD7 (NP_005895. 1).
  
  Purification
  
  Affinity purification
  
  Conjugate
  
  Unconjugated
  
  Formulation
  
  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  
  Storage
  
  Store at -20°C and avoid freeze-thaw cycles.
  
  Regulatory Status
  
  RUO
  
  Antigen
  
  Mothers Against Decapentaplegic Homolog 7; Mad Homolog 7; Mothers Against Dpp Homolog 7; Mothers Against Decapentaplegic Homolog 8; Mad Homolog 8; Mothers Against Dpp Homolog 8; Smad Family Member 7; Smad 7; Smad7; Hsmad7 (Gene ID:4092; UniProt:O15105)
  
  * For research use only