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Overview
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SGK1 is a protein encoded by the SGK1 gene which is approximately 48, 9 kDa. SGK1 is localised to the cytoplasm, nucleus, cell membrane, mitochondrion and endoplasmic reticulum membrane. It is involved in the mTOR signalling pathway, gene expression, ion channel transport, and regulation of TP53 activity. It activates certain potassium, sodium, and chloride channels, suggesting an involvement in the regulation of processes such as cell survival, neuronal excitability, and renal sodium excretion. SGK1 is expressed in most tissues with highest levels in the pancreas. Mutations in the SGK1 gene may result in pseudohypoaldosteronism and Liddle syndrome. STJ95633 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of SGK1 protein.
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