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Overview
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RUNX2 is a protein encoded by the RUNX2 gene which is approximately 56, 6 kDa. RUNX2 is localised to the nucleus. It is involved in gene expression, transcriptional misregulation in cancer, the dendritic cell developmental lineage pathway and the notch signalling pathway. It is essential for osteoblastic differentiation and skeletal morphogenesis and acts as a scaffold for nucleic acids and regulatory factors involved in skeletal gene expression. RUNX2 is specifically expressed in osteoblasts. Mutations in the RUNX2 gene may result in cleidocranial dysplasia. STJ96721 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of RUNX2 protein.
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