Name: Anti-RUNX2 antibody
Price: 297.00 USD

Overview
- This gene is a member of the RUNX family of transcription factors and encodes a nuclear protein with an Runt DNA-binding domain. This protein is essential for osteoblastic differentiation and skeletal morphogenesis and acts as a scaffold for nucleic acids and regulatory factors involved in skeletal gene expression. The protein can bind DNA both as a monomer or, with more affinity, as a subunit of a heterodimeric complex. Two regions of potential trinucleotide repeat expansions are present in the N-terminal region of the encoded protein, and these and other mutations in this gene have been associated with the bone development disorder cleidocranial dysplasia (CCD). Transcript variants that encode different protein isoforms result from the use of alternate promoters as well as alternate splicing.
  
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Properties
- Host
  
  rabbit
  
  Antibody Type
  
  polyclonal
  
  Isotype
  
  IgG
  
  Reactivity
  
  human; mouse
  
  Immunogen
  
  Recombinant fusion protein containing a sequence corresponding to amino acids 242-521 of human RUNX2 (NP_001019801. 3).
  
  Purification
  
  Affinity purification
  
  Conjugate
  
  Unconjugated
  
  Formulation
  
  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  
  Storage
  
  Store at -20°C and avoid freeze-thaw cycles.
  
  Regulatory Status
  
  RUO
  
  Antigen
  
  Runt-Related Transcription Factor 2; Acute Myeloid Leukemia 3 Protein; Core-Binding Factor Subunit Alpha-1; Cbf-Alpha-1; Oncogene Aml-3; Osteoblast-Specific Transcription Factor 2; Osf-2; Polyomavirus Enhancer-Binding Protein 2 Alpha A Subunit; Pea2-Alpha A; Pebp2-Alpha A; Sl3-3 Enhancer Factor 1 Alpha A Subunit; Sl3/Akv Core-Binding Factor Alpha A Subunit (Gene ID:860; UniProt:Q13950)
  
  * For research use only