Name: Anti-RPSA antibody
Price: 297.00 USD

Overview
- Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Many of the effects of laminin are mediated through interactions with cell surface receptors. These receptors include members of the integrin family, as well as non-integrin laminin-binding proteins. This gene encodes a high-affinity, non-integrin family, laminin receptor 1. This receptor has been variously called 67 kD laminin receptor, 37 kD laminin receptor precursor (37LRP) and p40 ribosome-associated protein. The amino acid sequence of laminin receptor 1 is highly conserved through evolution, suggesting a key biological function. It has been observed that the level of the laminin receptor transcript is higher in colon carcinoma tissue and lung cancer cell line than their normal counterparts. Also, there is a correlation between the upregulation of this polypeptide in cancer cells and their invasive and metastatic phenotype. Multiple copies of this gene exist, however, most of them are pseudogenes thought to have arisen from retropositional events. Two alternatively spliced transcript variants encoding the same protein have been found for this gene.
  
  Please contact us at for specific academic pricing.
Properties
- Host
  
  rabbit
  
  Antibody Type
  
  polyclonal
  
  Isotype
  
  IgG
  
  Reactivity
  
  mouse
  
  Immunogen
  
  Recombinant fusion protein containing a sequence corresponding to amino acids 1-295 of human RPSA (NP_002286. 2).
  
  Purification
  
  Affinity purification
  
  Conjugate
  
  Unconjugated
  
  Formulation
  
  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  
  Storage
  
  Store at -20°C and avoid freeze-thaw cycles.
  
  Regulatory Status
  
  RUO
  
  Antigen
  
  40s Ribosomal Protein Sa; 37 Kda Laminin Receptor Precursor; 37lrp; 37/67 Kda Laminin Receptor; Lrp/Lr; 67 Kda Laminin Receptor; 67lr; Colon Carcinoma Laminin-Binding Protein; Laminin Receptor 1; Lamr; Laminin-Binding Protein Precursor P40; Lbp/P40; Multidrug Resistance-Associated Protein Mgr1-Ag; Nem/1chd4; Small Ribosomal Subunit Protein Us2 (Gene ID:3921; UniProt:P08865)
  
  * For research use only