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Overview
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Rho A is a protein encoded by the RHOA gene which is approximately 21, 7 kDa. Rho A is localised to the cell membrane and cytoplasm. It is involved in p75 NTR receptor-mediated signalling, semaphorin interactions, the S1P3 pathway, blood-brain barrier and immune cell transmigration. This protein falls under the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. It promotes the reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. Rho A is expressed in the nervous system, blood, eye, intestine and lung. Mutations in the RHOA gene may result in colorectal cancer and cervix carcinoma. STJ95442 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of Rho A protein.
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