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Overview
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Recognizes junctional adhesion molecule-A (JAM-A), also known as JAM-1 and the mouseplatelet F11-Receptor (F11R), is a cell adhesion molecule (CAM). JAM-A is a member of theimmunoglobulin superfamily found on the surface of mouse platelets and at intercellular junctions ofendothelial cells and epithelial cells. JAM-A belongs together with JAM-B (VE-JAM or JAM-3) and JAM-C(JAM-2) to a family of adhesion proteins with a V-C2 immunoglobulin domain organization. JAM plays animportant role in tight junctions where it is involved in cell-to-cell adhesion through hemophilicinteraction. It co-distributes with other tight junction components as ZO-1, 7H6 antigen, cingulin andoccludin. In human JAM-A plays a role in platelet aggregation, secretion, adhesion and spreading.
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