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                                            Overview
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                                                    Please contact us at for specific academic pricing. BackgroundCD45 is a 180-220 kD protein also known as leukocyte common antigen (LCA). It is a protein tyrosine phosphatase with multiple isoforms differing as a result of alternative splicing of the extracellular domain and glycosylation. CD45 is expressed on all hematopoietic cells except erythrocytes and platelets; isoform expression depends on cell type, activation state, and cell maturation. CD45 functions in signal transduction through T and B cell antigen receptors. CD45 has been shown to interact with various proteins including galectin-1, CD2, CD3, and CD4. The OX-1 antibody has been shown to partially inhibit NK cell-mediated lysis of syngeneic tumor cells in vitro. 
 
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                                    ![Mouse IgM, κ Isotype Control ( AF647 Conjugated ) [MM-30] (0.5 mg/mL) for Flow Cytometry](https://resource.amerigoscientific.com/p-img/reddot_antibodies.jpg) 
                                                                                                         
                    