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Overview
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RANKL is a protein encoded by the TNFSF11 gene which is approximately 35, 4 kDa. RANKL isoform 1 and 3 are localised to the cell membrane and isoform 2 is localised to the cytoplasm. It is involved in PEDF induced signalling, ERK signalling, RANK signalling in osteoclasts and Akt signalling. This protein falls under the tumour necrosis factor cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. It has been shown to be a dendritic cell survival factor and is involved in the regulation of T cell-dependent immune response. RANKL is expressed highest in the peripheral lymph nodes. Mutations in the TNFSF11 gene may result in osteopetrosis. STJ96769 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of RANKL protein.
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Overview
Immunohistochemical analysis of paraffin-embedded human-Lymph-nodes, antibody was diluted at 1:100 Western blot analysis of lysate from 293 cells, using TNFSF11 Antibody.
Immunohistochemical analysis of paraffin-embedded human-lung, antibody was diluted at 1:100 Immunohistochemical analysis of paraffin-embedded human-Lymph-nodes, antibody was diluted at 1:100 Immunohistochemical analysis of paraffin-embedded human-lung, antibody was diluted at 1:100 Western blot analysis of 293 cells using RANKL Polyclonal Antibody.. Secondary antibody was diluted at 1:20000 Immunohistochemical analysis of paraffin-embedded Mouse-kidney tissue. 1, RANKL Polyclonal Antibody was diluted at 1:200 (4°C, overnight). 2, Sodium citrate pH 6.0 was used for antibody retrieval (>98°C, 20min). 3, Secondary antibody was diluted at 1:200 (room tempeRature, 30min). Negative control was used by secondary antibody only.
Immunohistochemical analysis of paraffin-embedded Rat-lung tissue. 1, RANKL Polyclonal Antibody was diluted at 1:200 (4°C, overnight). 2, Sodium citrate pH 6.0 was used for antibody retrieval (>98°C, 20min). 3, Secondary antibody was diluted at 1:200 (room tempeRature, 30min). Negative control was used by secondary antibody only.
Immunohistochemical analysis of paraffin-embedded Human-uterus tissue. 1, RANKL Polyclonal Antibody was diluted at 1:200 (4°C, overnight). 2, Sodium citrate pH 6.0 was used for antibody retrieval (>98°C, 20min). 3, Secondary antibody was diluted at 1:200 (room tempeRature, 30min). Negative control was used by secondary antibody only.
Anti-RANKL antibody
Anti-RANKL antibody
Catalog Number:
A001052139STJ
Mfr. No.:
STJ96769
Price:
$224
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