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Overview
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RANKL is a protein encoded by the TNFSF11 gene which is approximately 35, 4 kDa. RANKL isoform 1 and 3 are localised to the cell membrane and isoform 2 is localised to the cytoplasm. It is involved in PEDF induced signalling, ERK signalling, RANK signalling in osteoclasts and Akt signalling. This protein falls under the tumour necrosis factor cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. It has been shown to be a dendritic cell survival factor and is involved in the regulation of T cell-dependent immune response. RANKL is expressed highest in the peripheral lymph nodes. Mutations in the TNFSF11 gene may result in osteopetrosis. STJ96769 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of RANKL protein.
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