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Overview
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Radixin is a protein encoded by the RDX gene which is approximately 68, 5 kDa. Radixin is localised to the cell membrane. it is involved in regulation of actin cytoskeleton, proteoglycans in cancer, developmental biology and blood-brain barrier and immune cell transmigration. It is a cytoskeletal protein that may be important in linking actin to the plasma membrane. It may also play a crucial role in the binding of the barbed end of actin filaments to the plasma membrane. It is highly similar in sequence to both ezrin and moesin. Radixin is expressed in the nervous system, liver, eye, heart and kidney. Mutations in the RDX gene may result in deafness. STJ95338 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of Radixin protein.
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