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Overview
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PUMA is a protein encoded by the BBC3 gene which is approximately 26, 5 kDa. PUMA is localised to the mitochondrion. It is involved in apoptosis modulation and signalling, activation of BH3-only proteins, DNA damage response and CDK-mediated phosphorylation and removal of Cdc6. This protein falls under the BCL-2 protein family. It cooperates with direct activator proteins to induce mitochondrial outer membrane permeabilization and apoptosis. It can bind to anti-apoptotic Bcl-2 family members to induce mitochondrial dysfunction and caspase activation. It is also an essential mediator of p53/TP53-dependent and p53/TP53-independent apoptosis. PUMA is expressed ubiquitously. STJ95272 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of PUMA protein.
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