Name: Anti-POMC antibody
Price: 297.00 USD

Overview
- This gene encodes a preproprotein that undergoes extensive, tissue-specific, post-translational processing via cleavage by subtilisin-like enzymes known as prohormone convertases. There are eight potential cleavage sites within the preproprotein and, depending on tissue type and the available convertases, processing may yield as many as ten biologically active peptides involved in diverse cellular functions. The encoded protein is synthesized mainly in corticotroph cells of the anterior pituitary where four cleavage sites are used; adrenocorticotrophin, essential for normal steroidogenesis and the maintenance of normal adrenal weight, and lipotropin beta are the major end products. In other tissues, including the hypothalamus, placenta, and epithelium, all cleavage sites may be used, giving rise to peptides with roles in pain and energy homeostasis, melanocyte stimulation, and immune modulation. These include several distinct melanotropins, lipotropins, and endorphins that are contained within the adrenocorticotrophin and beta-lipotropin peptides. The antimicrobial melanotropin alpha peptide exhibits antibacterial and antifungal activity. Mutations in this gene have been associated with early onset obesity, adrenal insufficiency, and red hair pigmentation. Alternatively spliced transcript variants encoding the same protein have been described.
  
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Properties
- Host
  
  rabbit
  
  Antibody Type
  
  polyclonal
  
  Isotype
  
  IgG
  
  Reactivity
  
  human; mouse; rat
  
  Immunogen
  
  Recombinant fusion protein containing a sequence corresponding to amino acids 1-267 of human POMC (NP_000930. 1).
  
  Purification
  
  Affinity purification
  
  Conjugate
  
  Unconjugated
  
  Formulation
  
  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  
  Storage
  
  Store at -20°C and avoid freeze-thaw cycles.
  
  Regulatory Status
  
  RUO
  
  Antigen
  
  Pro-Opiomelanocortin; Pomc; Corticotropin-Lipotropin Cleaved Into-Npp-Melanotropin Gamma; Gamma-Msh-Potential Peptide-Corticotropin; Adrenocorticotropic Hormone; Acth-Melanocyte-Stimulating Hormone Alpha; Alpha-Msh; Melanotropin Alpha-Corticotropin-Like Intermediary Peptide; Clip-Lipotropin Beta; Beta-Lph-Lipotropin Gamma; Gamma-Lph-Melanocyte-Stimulating Hormone Beta; Beta-Msh; Melanotropin Beta-Beta-Endorphin-Met-Enkephalin (Gene ID:5443; UniProt:P01189)
  
  * For research use only