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Overview
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Stat3 is a protein encoded by the STAT3 gene which is approximately 88 kDa. Stat3 is localised to the cytoplasm and nucleus. It is involved in the immune response IL-23 signalling pathway, RET signalling, Th17 cell differentiation and prolactin signalling pathway. This protein falls under the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by receptor associated kinases, and then form homo-or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. Stat3 is expressed in the heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Mutations in the STAT3 gene may result in Hyperimmunoglobulin E recurrent infection syndrome. STJ90411 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This primary antibody specifically binds to endogenous Stat3 protein which only binds about Y705 when Y705 is phosphorylated.
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