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Overview
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Raf-1 is a protein encoded by the RAF1 gene which is approximately 73 kDa. Raf-1 is localised to the cytoplasm, cell membrane, mitochondrion and nucleus. It is involved in RET signalling, the IL-2 pathway, regulation of lipid metabolism and insulin signalling-generic cascades. When it is activated, the cellular RAF1 protein can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylates to activate the serine/threonine specific protein kinases, ERK1 and ERK2. It plays an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration. Raf-1 is expressed in skeletal muscle with isoform 1 is more abundant than isoform 2. Mutations in the RAF1 gene result in Noonan syndrome, Leopard syndrome and cardiomyopathy. The antibody STJ90399 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This primary antibody specifically binds to endogenous Raf-1 protein which only binds about S259 when S259 is phosphorylated.
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