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Overview
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PP1 alpha is a protein encoded by the PPP1CA gene which is approximately 37, 5 kDa. PP1 alpha is localised to the cytoplasm and nucleus. It is involved in vascular smooth muscle contraction, regulation of lipid metabolism and insulin signalling-generic cascades. It is one of the three catalytic subunits of protein phosphatase 1. It is an enzyme that catalyses the removal of phosphate groups from serine and/or threonine residues by hydrolysis of phosphoric acid monoesters. They oppose the action of kinases and phosphorylases and are involved in signal transduction. PP1 alpha is expressed in the lung, muscle, blood, pancreas and liver. Increased activity of this protein has been observed in the end stage of heart failure. STJ91134 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This primary antibody specifically binds to endogenous PP1 alpha protein which only binds about T320 when T320 is phosphorylated.
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