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Overview
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p53 is a protein encoded by the TP53 gene which is approximately 43, 6 kDa. p53 is localised to the cytoplasm, nucleus and endoplasmic reticulum. It is involved in RET signalling, CDK-mediated phosphorylation and removal of Cdc6, glioma and apoptotic pathways. It is a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. It responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest and changes in metabolism. p53 is expressed ubiquitously. Mutations in the TP53 gene may result in Li-Fraumeni syndrome and choroid plexus papilloma. STJ90365 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This primary antibody specifically binds to endogenous p53 protein which only binds about S15 when S15 is phosphorylated.
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