Name: Anti-Phospho-INPP5D-(Y1020) antibody
Price: 295.00 USD

Overview
- This gene is a member of the inositol polyphosphate-5-phosphatase (INPP5) family and encodes a protein with an N-terminal SH2 domain, an inositol phosphatase domain, and two C-terminal protein interaction domains. Expression of this protein is restricted to hematopoietic cells where its movement from the cytosol to the plasma membrane is mediated by tyrosine phosphorylation. At the plasma membrane, the protein hydrolyzes the 5' phosphate from phosphatidylinositol (3, 4, 5)-trisphosphate and inositol-1, 3, 4, 5-tetrakisphosphate, thereby affecting multiple signaling pathways. The protein is also partly localized to the nucleus, where it may be involved in nuclear inositol phosphate signaling processes. Overall, the protein functions as a negative regulator of myeloid cell proliferation and survival. Mutations in this gene are associated with defects and cancers of the immune system. Alternative splicing of this gene results in multiple transcript variants.
  
  Please contact us at for specific academic pricing.
Properties
- Host
  
  rabbit
  
  Antibody Type
  
  polyclonal
  
  Isotype
  
  IgG
  
  Reactivity
  
  human
  
  Immunogen
  
  A synthetic phosphorylated peptide around Y1020 of human INPP5D (NP_001017915. 1).
  
  Purification
  
  Affinity purification
  
  Conjugate
  
  Unconjugated
  
  Formulation
  
  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  
  Storage
  
  Store at -20°C and avoid freeze-thaw cycles.
  
  Regulatory Status
  
  RUO
  
  Antigen
  
  Phosphatidylinositol 3-4-5-Trisphosphate 5-Phosphatase 1; Inositol Polyphosphate-5-Phosphatase D; Inositol Polyphosphate-5-Phosphatase Of 145 Kda; Sip-145; Phosphatidylinositol 4-5-Bisphosphate 5-Phosphatase; Sh2 Domain-Containing Inositol 5'-Phosphatase 1; Sh2 Domain-Containing Inositol Phosphatase 1; Ship-1; P150ship; Hp51cn (Gene ID:3635; UniProt:Q92835)
  
  * For research use only