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Overview
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Histone H3 is a protein encoded by the HIST3H3 gene which is approximately 15, 5 kDa. Histone H3 is localised to the nucleus and chromosome. It is involved in the DNA double-strand break repair and mitotic cell cycle. This protein falls under the histone family protein. Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). Histones play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. Histone H3 is expressed in the testicular cells. STJ90289 was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen. This primary antibody specifically binds to endogenous Histone H3 protein which only binds about S10 when S10 is phosphorylated.
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