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Overview
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Bim is a protein encoded by the BCL2L11 gene which is approximately 22, 1 kDa. Bim is localised to the mitochondrion. It is involved in the activation of BH3-only proteins, apoptosis modulation and signalling, p75 NTR receptor-mediated signalling and MAPK signalling. It forms a hetero-or homodimers and acts as anti-or pro-apoptotic regulator that is involved in a wide variety of cellular activities. Bim isoform gamma is most abundantly expressed in small intestine and colon. Other isoforms are widely expressed with tissue-specific variation. Mutations in the BCL2L11 gene may result in ocular hyperemia and autoimmune lymphoproliferative syndrome. STJ91225 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This primary antibody specifically binds to endogenous Bim protein which only binds about S59 when S59 is phosphorylated.
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