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Overview
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PERK is a protein encoded by the EIF2AK3 gene which is approximately 125, 2 kDa. PERK is localised to the endoplasmic reticulum membrane. It is involved in respiratory electron transport, apoptosis modulation and signalling and animal autophagy. It phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2, leading to its inactivation, and a rapid reduction of translational initiation and repression of global protein synthesis. PERK is expressed in the nervous system, liver, pancreas, lung and heart. Mutations in the EIF2AK3 gene may result in Wolcott-Rallison syndrome and diversion colitis. STJ95031 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of PERK protein only when phosphorylated at T981.
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