Name: Anti-PEG10 antibody
Price: 297.00 USD

Overview
- This is a paternally expressed imprinted gene that is thought to have been derived from the Ty3/Gypsy family of retrotransposons. It contains two overlapping open reading frames, RF1 and RF2, and expresses two proteins: a shorter, gag-like protein (with a CCHC-type zinc finger domain) from RF1; and a longer, gag/pol-like fusion protein (with an additional aspartic protease motif) from RF1/RF2 by-1 translational frameshifting (-1 FS). While-1 FS has been observed in RNA viruses and transposons in both prokaryotes and eukaryotes, this gene represents the first example of-1 FS in a eukaryotic cellular gene. This gene is highly conserved across mammalian species and retains the heptanucleotide (GGGAAAC) and pseudoknot elements required for-1 FS. It is expressed in adult and embryonic tissues (most notably in placenta) and reported to have a role in cell proliferation, differentiation and apoptosis. Overexpression of this gene has been associated with several malignancies, such as hepatocellular carcinoma and B-cell lymphocytic leukemia. Knockout mice lacking this gene showed early embryonic lethality with placental defects, indicating the importance of this gene in embryonic development. Additional isoforms resulting from alternatively spliced transcript variants, and use of upstream non-AUG (CUG) start codon have been reported for this gene.
  
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Properties
- Host
  
  rabbit
  
  Antibody Type
  
  polyclonal
  
  Isotype
  
  IgG
  
  Reactivity
  
  human
  
  Immunogen
  
  Recombinant fusion protein containing a sequence corresponding to amino acids 1-325 of human PEG10 (NP_001035242. 1).
  
  Purification
  
  Affinity purification
  
  Conjugate
  
  Unconjugated
  
  Formulation
  
  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  
  Storage
  
  Store at -20°C and avoid freeze-thaw cycles.
  
  Regulatory Status
  
  RUO
  
  Antigen
  
  Retrotransposon-Derived Protein Peg10; Embryonal Carcinoma Differentiation-Regulated Protein; Mammalian Retrotransposon-Derived Protein 2; Myelin Expression Factor 3-Like Protein 1; Mef3-Like Protein 1; Paternally Expressed Gene 10 Protein; Retrotransposon Gag Domain-Containing Protein 3; Retrotransposon-Derived Gag-Like Polyprotein; Ty3/Gypsy-Like Protein (Gene ID:23089; UniProt:Q86TG7)
  
  * For research use only