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Overview
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Fibrillar collagen types I-III are synthesized as precursor molecules known as procollagens. These precursors contain amino-and carboxyl-terminal peptide extensions known as N-and C-propeptides, respectively, which are cleaved, upon secretion of procollagen from the cell, to yield the mature triple helical, highly structured fibrils. This gene encodes a glycoprotein which binds and drives the enzymatic cleavage of type I procollagen and heightens C-proteinase activity.
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Overview