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Overview
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p21 is a protein encoded by the CDKN1A gene which is approximately 18, 1 kDa. p21 is localised to the cytoplasm and nucleus. It is involved in CDK-mediated phosphorylation and removal of Cdc6, RET signalling, cyclins and cell cycle regulation. It may be involved in p53/TP53 mediated inhibition of cellular proliferation in response to DNA damage. It binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression. It also functions in the nuclear localization and assembly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1. p21 is expressed in all adult tissues, with lower levels expressed in the brain. Mutations in the CDKN1A gene may result in pancreatic cancer and ovarian cancer. STJ94862 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of p21 protein.
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