Name: Anti-NUDT15 antibody
Price: 297.00 USD

Overview
- This gene encodes an enzyme that belongs to the Nudix hydrolase superfamily. Members of this superfamily catalyze the hydrolysis of nucleoside diphosphates, including substrates like 8-oxo-dGTP, which are a result of oxidative damage, and can induce base mispairing during DNA replication, causing transversions. The encoded enzyme is a negative regulator of thiopurine activation and toxicity. Mutations in this gene result in poor metabolism of thiopurines, and are associated with thiopurine-induced early leukopenia. Multiple pseudogenes of this gene have been identified.
  
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Properties
- Host
  
  rabbit
  
  Antibody Type
  
  polyclonal
  
  Isotype
  
  IgG
  
  Reactivity
  
  human
  
  Immunogen
  
  Recombinant fusion protein containing a sequence corresponding to amino acids 1-164 of human NUDT15 (NP_060753. 1).
  
  Purification
  
  Affinity purification
  
  Conjugate
  
  Unconjugated
  
  Formulation
  
  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  
  Storage
  
  Store at -20°C and avoid freeze-thaw cycles.
  
  Regulatory Status
  
  RUO
  
  Antigen
  
  Nucleotide Triphosphate Diphosphatase Nudt15; Mutt Homolog 2; Mth2; Nucleoside Diphosphate-Linked Moiety X Motif 15; Nudix Motif 15; Nucleoside Diphosphate-Linked To Another Moiety X Hydrolase 15; Nudix Hydrolase 15 (Gene ID:55270; UniProt:Q9NV35)
  
  * For research use only