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Overview
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Neuregulin-1 SMDF is a protein encoded by the NRG1 gene which is approximately 70, 3 kDa. Neuregulin-1 SMDF is secreted and some isoforms are localised to the nucleus. It is involved in RET signalling, apoptotic pathways in synovial fibroblasts, GAB1 signalosome and the GPCR pathway. It mediates cell-cell signalling and plays a critical role in the growth and development of multiple organ systems. It is also a direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Neuregulin-1 SMDF isoform type 1 is the predominant form expressed in the endocardium. Mutations in the NRG1 gene may result in schizophrenia and bipolar disorder. STJ94419 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of Neuregulin-1 SMDF protein.
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