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Overview
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NFkappaB-p105/p50 is a protein encoded by the NFKB1 gene which is approximately 105, 3 kDa. NFkappaB-p105/p50 is localised to the nucleus and cytoplasm. It is involved in activated TLR4 signalling, the TNFR1 pathway, toll-like receptor signalling pathways and 4-1BB pathway. It is a pleiotropic transcription factor that acts as the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. Dimers bind at kappa-B sites in the DNA of their target genes. Different dimer combinations act as transcriptional activators or repressors, respectively. NFkappaB-p105/p50 is expressed in the nervous system, liver, muscle, eye and lymph node. Mutations in the NFKB1 gene may result in common variable immunodeficiency and intestinal perforation. STJ94466 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of NFkappaB-p105/p50 protein.
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