Anti-MYC antibody

Catalog Number:
STJ111071
Price:
$874
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      • Overview
        • The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of non-AUG initiated protein is suppressed in Burkitt's lymphomas, suggesting its importance in the normal function of this gene.

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      • Properties
        • Host
          rabbit
          Antibody Type
          polyclonal
          Isotype
          IgG
          Reactivity
          human; mouse; rat
          Immunogen
          A synthetic peptide corresponding to a sequence within amino acids 1-100 of human MYC (NP_002458. 2).
          Purification
          Affinity purification
          Conjugate
          Unconjugated
          Formulation
          PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
          Storage
          Store at -20°C and avoid freeze-thaw cycles.
          Regulatory Status
          RUO
          Antigen
          Myc Proto-Oncogene Protein; Class E Basic Helix-Loop-Helix Protein 39; Bhlhe39; Proto-Oncogene C-Myc; Transcription Factor P64 (Gene ID:4609; UniProt:P01106)

          * For research use only

      • Applications
        • Application
          WB
        • Application Dilutions
          WB 1:500-1:2000
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