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Overview
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Reacts with an internal epitope of MRP3, a 190-200 kD transmembrane protein that isclosely related to the multidrug resistance protein MRP1. M3II-21 was raised against a bacterial fusionprotein of MRP3, containing amino acids 830-949 of the protein. M3II-21 does not cross-react with thehuman MDR1, MRP1, MRP2 or MRP5 gene products. M3II-21 has potential value for detection ofMRP3-mediated drug-resistance in human tumor samples.
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