Name: Anti-MRE11 antibody
Price: 224.00 USD

Overview
- MRE11 is a protein encoded by the MRE11 gene which is approximately 80, 5 kDa. MRE11 is localised to the nucleus and is involved in DNA double-strand break repair, cytosolic sensors of pathogen-associated DNA and telomere length maintenance. By itself, the protein has 3' to 5' exonuclease activity and endonuclease activity. In conjunction with a DNA ligase, it promotes the joining of noncomplementary ends in vitro using short homologies near the ends of the DNA fragments. MRE11 is expressed in the nervous system, liver and blood. Mutations in the MRE11 gene may result in ataxia-telangiectasia-like disorder, Nijmegen breakage syndrome and hereditary breast ovarian cancer. STJ94194 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of MRE11 protein.
  
  Please contact us at for specific academic pricing.
Properties
- Host
  
  rabbit
  
  Antibody Type
  
  polyclonal
  
  Isotype
  
  IgG
  
  Reactivity
  
  human; mouse; rat; monkey
  
  Immunogen
  
  Synthesized peptide derived from human MRE11 around the non-phosphorylation site of S264.
  
  Purification
  
  The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  
  Conjugate
  
  Unconjugated
  
  Formulation
  
  Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  
  Storage
  
  Store at -20°C and avoid repeat freeze-thaw cycles.
  
  Concentration
  
  1 mg/ml
  
  Regulatory Status
  
  RUO
  
  Antigen
  
  Double-strand break repair protein MRE11; Double-strand break repair protein MRE11A; Meiotic recombination 11 homolog 1; MRE11 homolog 1; Meiotic recombination 11 homolog A; MRE11 homolog A (Gene ID:4361; UniProt:P49959)
  
  * For research use only

Applications

Application

WB; IHC (paraffin); ELISA

Application	Dilutions
WB	1:500-1:2000
IHC	1:100-1:300
ELISA	1:20000

Western blot analysis of lysates from Jurkat cells, treated with UV 15', using MRE11 Antibody. The lane on the right is blocked with the synthesized peptide.

Western blot analysis of COS7 cells using MRE11 Polyclonal Antibody cells nucleus extracted by Minute TM Cytoplasmic and Nuclear Fractionation kit (SC-003, Inventbiotech, MN, USA).

Immunohistochemical analysis of paraffin-embedded Human brain. Antibody was diluted at 1:100 (4°C overnight). High-pressure and temperature Tris-EDTA, pH8.0 was used for antigen retrieval. Negetive contrl (right) obtaned from antibody was pre-absorbed by immunogen peptide.

Western blot analysis of various cells using MRE11 Polyclonal Antibody cells nucleus extracted by Minute TM Cytoplasmic and Nuclear Fractionation kit (SC-003, Inventbiotech, MN, USA).

Anti-MRE11 antibody

Anti-MRE11 antibody

Western blot analysis of lysates from Jurkat cells, treated with UV 15', using MRE11 Antibody. The lane on the right is blocked with the synthesized peptide.

Western blot analysis of COS7 cells using MRE11 Polyclonal Antibody cells nucleus extracted by Minute TM Cytoplasmic and Nuclear Fractionation kit (SC-003, Inventbiotech, MN, USA).

Immunohistochemical analysis of paraffin-embedded Human brain. Antibody was diluted at 1:100 (4°C overnight). High-pressure and temperature Tris-EDTA, pH8.0 was used for antigen retrieval. Negetive contrl (right) obtaned from antibody was pre-absorbed by immunogen peptide.

Western blot analysis of various cells using MRE11 Polyclonal Antibody cells nucleus extracted by Minute TM Cytoplasmic and Nuclear Fractionation kit (SC-003, Inventbiotech, MN, USA).

Anti-MRE11 antibody

Anti-MRE11 antibody

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