Name: Anti-Mouse IL-1R In Vivo Antibody - Low Endotoxin (JAMA-147)
Price: 680.00 USD

- Overview
  - Specificity: Anti-IL-1R In Vivo Antibody - Low Endotoxin (JAMA-147) recognizes Mouse IL-1 R1
    Purification method: This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype.
    Isotype Control: Armenian Hamster IgG Isotype Control for In Vivo - Low Endotoxin [PIP] (ICH2251)
    Endotoxin: ≤ 1.0 EU/mg as determined by the LAL method
    Aggregation: Aggregation level ≤ 5%
    
    Please contact us at for specific academic pricing.
    
    Background
    
    IL-1 binds two receptors, IL-1RI and IL-1RII. The ligands IL-1alpha and IL-1beta exert all of their various biological actions by binding IL-1RI. IL-1RII has a shortened cytoplasmic domain that is unable to transduce signals and therefore acts as a decoy receptor and competitively antagonizes the binding of IL-1alpha and IL-1beta, thereby reducing their biological effects. Binding of the ligands to IL-1RI is enhanced by an accessory protein, IL-1R-AcP. IL-1RI is expressed on T cells, thymocytes, dendritic cells, fibroblasts, vascular endothelial cells, epithelial cells and neural cells. It is an 80 kD transmembrane glycoprotein.
- Properties
  - Host
    
    armenian hamster
    
    Isotype
    
    IgG
    
    Reactivity
    
    mouse
    
    Clone
    
    JAMA-147
    
    Immunogen
    
    Extracellular domain of mouse IL-1 R type 1
    
    Purification
    
    >95% by SDS-PAGE and HPLC
    
    Formulation
    
    0.01 M phosphate buffered saline (PBS) pH 7.2, 150 mM NaCl with no carrier protein, potassium or preservatives added.
    
    Storage
    
    anti-IL-1R In Vivo Antibody - Low Endotoxin (JAMA-147) is stable for at least one week when stored sterile at 2-8°C. For long term storage aseptically aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles
    
    Molecular Weight
    
    1.0 - 5.0 mg/ml
    
    Regulatory Status
    
    Each investigator should determine their own optimal working dilution for specific applications.
    
    Antigen
    
    (Gene ID:Interleukin-1 receptor type 1, IL-1R-1, IL-1RT-1, IL-1RT1, CD121 antigen-like family member A, Interleukin-1 receptor alpha, IL-1R-alpha, Interleukin-1 receptor type I, p80, CD121a)
    
    * Products are for research use only. Not for use in diagnostic or therapeutic procedures.
- Applications
  - Application
    
    Immunoprecipitation; WB; Blocking; Flow Cytometry

Anti-Mouse IL-1R In Vivo Antibody - Low Endotoxin (JAMA-147)

Anti-Mouse IL-1R In Vivo Antibody - Low Endotoxin (JAMA-147)

Background

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