Anti-Mouse IL-17A Monoclonal Antibody ( APC Conjugated ) for Flow Cytometry (intracellular)

Anti-Mouse IL-17A Monoclonal Antibody ( APC Conjugated ) for Flow Cytometry (intracellular)

Catalog Number:
A001086544RED
Mfr. No.:
RD22161F
Price:
$226
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      • Overview
        • Please contact us at for specific academic pricing.

          Background

          IL-17, also known as CTLA-8, is a T cell-expressed pleiotropic cytokine that exhibits a high degree of homology to a protein encoded by the ORF13 gene of herpes virus Saimiri. IL-17 is produced by Th cells (Th17) that are distinct from the traditional Th1- and Th2-cell subsets. IL-23 plays an important role in triggering IL-17 production. Both recombinant and natural IL-17 have been shown to exist as disulfide linked homodimers. IL-17 exhibits multiple biological activities on a variety of cells including: the induction of IL-6 and IL-8 production in fibroblasts, activation of NF-κB, and costimulation of T cell proliferation. IL-17 is an essential inflammatory mediator in the development of autoimmune diseases. Neutralization of IL-17 with monoclonal antibody is able to ameliorate the disease course.

      • Properties
        • Host
          rat
          Antibody Type
          monoclonal
          Isotype
          IgG1 kappa
          Reactivity
          mouse
          Conjugate
          APC
          Formulation
          PBS with 0.05% Proclin300, 1% BSA
          Storage
          Store at 2~8°C and protected from prolonged exposure to light. Do not freeze.
          Antigen
          Interleukin-17A; IL-17; IL-17A; Cytotoxic T-lymphocyte-associated antigen 8; CTLA-8; CTLA8 (Gene ID:16171; UniProt:Q62386)

          * For research use only.

      • Applications
        • Application
          Flow Cytometry (intracellular)

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