Name: Anti-Mouse CD115 In Vivo Antibody - Low Endotoxin (AFS98)
Price: 680.00 USD

- Overview
  - Antigen Distribution: Monocytes/macrophages, peritoneal exudate cells, plasmacytoid and conventional dendritic cells, osteoclasts
    Specificity: Anti-CD115 In Vivo Antibody - Low Endotoxin (AFS98) recognizes an epitope on Mouse M-CSFR
    Purification method: This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype.
    Isotype Control: Rat IgG2a In Vivo Isotype Control - Low Endotoxin [1-1] (ICH2244)
    Endotoxin: ≤ 1.0 EU/mg as determined by the LAL method
    Aggregation: Aggregation level ≤ 5%
    
    Please contact us at for specific academic pricing.
    
    Background
    
    Macrophage colony-stimulating factor (M-CSF, also termed CSF-1) receptor is an integral membrane tyrosine kinase, expressed in monocytes (macrophages and their progenitors) and drives growth and development of this blood cell lineage. It also triggers growth and development of mononuclear phagocytes and placental trophoblasts. M-CSF receptor is present in osteoclasts both at mRNA and protein levels. When M-CSF ligand specifically binds to the M-CSF receptor on osteoclasts, it induces receptor dimerization, activation and autophosphorylation of cytoplasmic tyrosine residues M-CSF and its receptor present as candidate therapeutic targets in states of inflammatory bone erosion.
- Properties
  - Host
    
    rat
    
    Isotype
    
    IgG2a kappa
    
    Reactivity
    
    mouse
    
    Clone
    
    AFS98
    
    Immunogen
    
    Purified Recombinant Mouse M-CSFR
    
    Purification
    
    >95% by SDS-PAGE and HPLC
    
    Formulation
    
    0.01 M phosphate buffered saline (PBS), pH 7.2 - 7.4 without azide or BSA.
    
    Storage
    
    anti-CD115 In Vivo Antibody - Low Endotoxin (AFS98) is stable when stored at 2-8°C. For long term storage aseptically aliquot in working volumes without diluting and store at –80°C. Avoid Repeated Freeze Thaw Cycles. and keep sterile.
    
    Molecular Weight
    
    1.0 - 5.0 mg/ml
    
    Regulatory Status
    
    Each investigator should determine their own optimal working dilution for specific applications.
    
    Antigen
    
    (Gene ID:Macrophage colony-stimulating factor 1 receptor, CSF-1 receptor (EC:2.7.10.1), CSF-1-R, CSF-1R, M-CSF-R, Proto-oncogene c-Fms, Csf1r, Csfmr, Fms)
    
    * Products are for research use only. Not for use in diagnostic or therapeutic procedures.
- Applications
  - Application
    
    WB; Blocking; Functional Assays; Flow Cytometry

Anti-Mouse CD115 In Vivo Antibody - Low Endotoxin (AFS98)

Anti-Mouse CD115 In Vivo Antibody - Low Endotoxin (AFS98)

Background

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