Anti-Mouse CD103 Monoclonal Antibody ( PE Conjugated ) (0.2 mg/mL) for Flow Cytometry

Anti-Mouse CD103 Monoclonal Antibody ( PE Conjugated ) (0.2 mg/mL) for Flow Cytometry

Catalog Number:
A001087151RED
Mfr. No.:
RD21020F
Price:
$216
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      • Overview
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          Background

          CD103 is a type I transmembrane glycoprotein known as αE integrin or Integrin αIEL chain. It belongs to the integrin family and is primarily found on intestinal intraepithelial lymphocytes (IEL). CD103 is also expressed on a subpopulation of lamina propria T cells, epithelial dendritic cells, lamina propria-derived dendritic cells, and a small subset of peripheral lymphocytes. T regulatory cells express high level of CD103. The CD103 expression on lymphocytes can be induced upon activation and TGF-β stimulation. In association with integrin β7, CD103 is expressed as αE/β7 heterodimer. Mature CD103 protein can be cleaved into 2 chains, a 150 kD (C-terminal) chain and a 25 kD (N-terminal) chain, which remain linked by disulfide bonds. CD103 binds to E-cadherin and mediates homing of lymphocytes to the intestinal epithelium.

      • Properties
        • Host
          rat
          Antibody Type
          monoclonal
          Isotype
          IgG2a kappa
          Reactivity
          mouse
          Conjugate
          PE
          Formulation
          PBS with 0.05% Proclin300, 1% BSA
          Storage
          Store at 2~8°C and protected from prolonged exposure to light. Do not freeze.
          Concentration
          0.2 mg/mL
          Antigen
          Integrin alpha-E; Itgae; Integrin alpha M290; CD103 (Gene ID:16407; UniProt:Q60677)

          * For research use only.

      • Applications
        • Application
          Flow Cytometry

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