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Overview
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MIF is a protein encoded by the MIF gene which is approximately 12, 4 kDa. MIF is secreted and localised to the cytoplasm. It is involved in the innate immune system, tyrosine metabolism, PEDF induced signalling and cell surface interactions at the vascular wall. It is a pro-inflammatory cytokine involved in the innate immune response to bacterial pathogens. It plays a role in the regulation of macrophage function in host defence through the suppression of anti-inflammatory effects of glucocorticoids. This lymphokine and the JAB1 protein form a complex in the cytosol near the peripheral plasma membrane, which may indicate an additional role in integrin signalling pathways. MIF is expressed in the lung, nervous system, skin, eye and blood. Mutations in the MIF gene may result in rheumatoid arthritis. STJ94126 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of MIF protein.
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