Name: Anti-MEK-1/2 antibody
Price: 224.00 USD

Overview
- MEK-1/2 is a protein encoded by the MAP2K1 gene which is approximately 43, 4 kDa. MEK-1/2 is localised to the cytoplasm and nucleus. It is involved in RET signalling, activated TLR4 signalling, the IL-2 pathway, regulation of lipid metabolism and insulin signalling-generic cascades. It acts as an integration point for multiple biochemical signals such as proliferation, differentiation, transcription regulation and development. It is also a dual-specificity kinase known for its involvement in the ERK pathway by activation of ERK1 and ERK2. MEK-1/2 is widely expressed with low levels in the brain. Mutations in the MAP2K1 gene may result in Cardiofaciocutaneous syndrome. STJ94080 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of MEK-1/2 protein.
  
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Properties
- Host
  
  rabbit
  
  Antibody Type
  
  polyclonal
  
  Isotype
  
  IgG
  
  Reactivity
  
  human; mouse; rat; monkey
  
  Immunogen
  
  Synthesized peptide derived from human MEK-1/2 around the non-phosphorylation site of S218/222.
  
  Purification
  
  The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  
  Conjugate
  
  Unconjugated
  
  Formulation
  
  Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  
  Storage
  
  Store at -20°C and avoid repeat freeze-thaw cycles.
  
  Concentration
  
  1 mg/ml
  
  Regulatory Status
  
  RUO
  
  Antigen
  
  Dual Specificity Mitogen-Activated Protein Kinase Kinase 1; Map Kinase Kinase 1; Mapkk 1; Mkk1; Erk Activator Kinase 1; Mapk/Erk Kinase 1; Mek 1 (Gene ID:5604; UniProt:Q02750)
  
  * For research use only