Name: Anti-MDM2 antibody
Price: 224.00 USD

Overview
- MDM2 is a protein encoded by the MDM2 gene which is approximately 55, 2 kDa. MDM2 is localised to the nucleus and cytoplasm. It is involved in RET signalling, GAB1 signalosome and the regulation of TP53 activity. It is a nuclear-localized E3 ubiquitin ligase that can promote tumour formation by targeting tumour suppressor proteins, such as p53, for proteasomal degradation. It is also a component of the TRIM28/KAP1-ERBB4-MDM2 complex which links the growth factor and DNA damage response pathways. MDM2 is ubiquitously expressed in human tissues. Mutations in the MDM2 gene may result in accelerated tumour formation. STJ96551 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of MDM2 protein.
  
  Please contact us at for specific academic pricing.
Properties
- Host
  
  rabbit
  
  Antibody Type
  
  polyclonal
  
  Isotype
  
  IgG
  
  Reactivity
  
  human
  
  Immunogen
  
  Synthesized peptide derived from human MDM2.
  
  Purification
  
  The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  
  Conjugate
  
  Unconjugated
  
  Formulation
  
  Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  
  Storage
  
  Store at -20°C and avoid repeat freeze-thaw cycles.
  
  Concentration
  
  1 mg/ml
  
  Regulatory Status
  
  RUO
  
  Antigen
  
  E3 Ubiquitin-Protein Ligase Mdm2; Double Minute 2 Protein; Hdm2; Oncoprotein Mdm2; Ring-Type E3 Ubiquitin Transferase Mdm2; P53-Binding Protein Mdm2 (Gene ID:4193; UniProt:Q00987)
  
  * For research use only