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Overview
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Mcl-1 is a protein encoded by the MCL1 gene which is approximately 37, 3 kDa. Mcl-1 is localised to the cell membrane, cytoplasm, mitochondrion and nucleus. It is involved in apoptosis modulation and signalling, the Jak-STAT signalling pathway, cytokine signalling in the immune system and the PI3K-Akt signalling pathway. It regulated of apoptosis and cell survival, and plays a role in the maintenance of viability but not of proliferation. Isoform 1 inhibits apoptosis while isoform 2 promotes apoptosis. Mcl-1 is expressed in the nervous system, blood, lung, bone marrow and liver. Mutations in the MCL1 gene may result in myeloid leukaemia and follicular lymphoma. STJ94044 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of Mcl-1 protein.
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