Name: Anti-MAPK14 antibody
Price: 297.00 USD

Overview
- The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various environmental stresses and proinflammatory cytokines. The activation requires its phosphorylation by MAP kinase kinases (MKKs), or its autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein with this kinase. The substrates of this kinase include transcription regulator ATF2, MEF2C, and MAX, cell cycle regulator CDC25B, and tumor suppressor p53, which suggest the roles of this kinase in stress related transcription and cell cycle regulation, as well as in genotoxic stress response. Four alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
  
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Properties
- Host
  
  rabbit
  
  Antibody Type
  
  polyclonal
  
  Isotype
  
  IgG
  
  Reactivity
  
  human; mouse
  
  Immunogen
  
  Recombinant fusion protein containing a sequence corresponding to amino acids 1-360 of human MAPK14 (NP_620581. 1).
  
  Purification
  
  Affinity purification
  
  Conjugate
  
  Unconjugated
  
  Formulation
  
  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  
  Storage
  
  Store at -20°C and avoid freeze-thaw cycles.
  
  Regulatory Status
  
  RUO
  
  Antigen
  
  Mitogen-Activated Protein Kinase 14; Map Kinase 14; Mapk 14; Cytokine Suppressive Anti-Inflammatory Drug-Binding Protein; Csaid-Binding Protein; Csbp; Map Kinase Mxi2; Max-Interacting Protein 2; Mitogen-Activated Protein Kinase P38 Alpha; Map Kinase P38 Alpha; Stress-Activated Protein Kinase 2a; Sapk2a (Gene ID:1432; UniProt:Q16539)
  
  * For research use only