Name: Anti-MAN2B1 antibody
Price: 297.00 USD

Overview
- This gene encodes an enzyme that hydrolyzes terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides. Its activity is necessary for the catabolism of N-linked carbohydrates released during glycoprotein turnover and it is member of family 38 of glycosyl hydrolases. The full length protein is processed in two steps. First, a 49 aa leader sequence is cleaved off and the remainder of the protein is processed into 3 peptides of 70 kDa, 42 kDa (D) and 13/15 kDa (E). Next, the 70 kDa peptide is further processed into three peptides (A, B and C). The A, B and C peptides are disulfide-linked. Defects in this gene have been associated with lysosomal alpha-mannosidosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
  
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Properties
- Host
  
  rabbit
  
  Antibody Type
  
  polyclonal
  
  Isotype
  
  IgG
  
  Reactivity
  
  mouse
  
  Immunogen
  
  Recombinant fusion protein containing a sequence corresponding to amino acids 640-850 of human MAN2B1 (NP_000519. 2).
  
  Purification
  
  Affinity purification
  
  Conjugate
  
  Unconjugated
  
  Formulation
  
  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  
  Storage
  
  Store at -20°C and avoid freeze-thaw cycles.
  
  Regulatory Status
  
  RUO
  
  Antigen
  
  Lysosomal Alpha-Mannosidase; Laman; Lysosomal Acid Alpha-Mannosidase; Mannosidase Alpha Class 2b Member 1; Mannosidase Alpha-B Cleaved Into-Lysosomal Alpha-Mannosidase A Peptide-Lysosomal Alpha-Mannosidase B Peptide-Lysosomal Alpha-Mannosidase C Peptide-Lysosomal Alpha-Mannosidase D Peptide-Lysosomal Alpha-Mannosidase E Peptide (Gene ID:4125; UniProt:O00754)
  
  * For research use only