Name: Anti-IL4R antibody
Price: 297.00 USD

Overview
- This gene encodes the alpha chain of the interleukin-4 receptor, a type I transmembrane protein that can bind interleukin 4 and interleukin 13 to regulate IgE production. The encoded protein also can bind interleukin 4 to promote differentiation of Th2 cells. A soluble form of the encoded protein can be produced by proteolysis of the membrane-bound protein, and this soluble form can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells. Allelic variations in this gene have been associated with atopy, a condition that can manifest itself as allergic rhinitis, sinusitus, asthma, or eczema. Polymorphisms in this gene are also associated with resistance to human immunodeficiency virus type-1 infection. Alternate splicing results in multiple transcript variants.
  
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Properties
- Host
  
  rabbit
  
  Antibody Type
  
  polyclonal
  
  Isotype
  
  IgG
  
  Reactivity
  
  human
  
  Immunogen
  
  Recombinant fusion protein containing a sequence corresponding to amino acids 26-232 of human IL4R (NP_000409. 1).
  
  Purification
  
  Affinity purification
  
  Conjugate
  
  Unconjugated
  
  Formulation
  
  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  
  Storage
  
  Store at -20°C and avoid freeze-thaw cycles.
  
  Regulatory Status
  
  RUO
  
  Antigen
  
  Interleukin-4 Receptor Subunit Alpha; Il-4 Receptor Subunit Alpha; Il-4r Subunit Alpha; Il-4r-Alpha; Il-4ra; Cd Antigen Cd124 Cleaved Into-Soluble Interleukin-4 Receptor Subunit Alpha; Soluble Il-4 Receptor Subunit Alpha; Soluble Il-4r-Alpha; Sil4ralpha/Prot; Il-4-Binding Protein; Il4-Bp (Gene ID:3566; UniProt:P24394)
  
  * For research use only