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Overview
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Anti-TTF-1 (Thyroid Transcription Factor 1) is useful in differentiating primary adenocarcinoma of thelung from metastatic carcinomas originating in the organs rather than thyroid, germ cell tumors, andmalignant mesothelioma. It can also be used to differentiate small cell lung carcinoma from lymphoidinfiltrates. TTF-1 labeling is also seen in thyroid and thyroid-derived tumors. TTF-1 immunostaining isuseful in the differentiation between pulmonary and nonpulmonary origin of adenocarcinomas inmalignant effusions. TTF-1 staining is very reliable in discerning whether a brain metastasis has arisenfrom a pulmonary or nonpulmonary site, particularly when dealing with adenocarcinomas and large-cell carcinomas.
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Overview